Carry it through screening on your body. Cargo pants will allow you to carry a quite large bankroll.
Your question is of course more relevant if the cash is discovered or inquired about by the screening personnel. Be completely honest about what you are carrying if asked. You might be interested in a recent article by Bob Nersesian in All In magazine. He describes a case where cash was confiscated. It was only around $30K or $40K if I recall correctly. After lots of legal wrangling, the cash was finally returned about a year later, and all 'charges' dropped.
However, in that case there were other factors including an international flight and a one-way ticket. If at all possible, avoid booking one way fares if you are carrying your bankroll. Also be careful about booking multi-carrier connections, since those flights often look like one-way fares. Pay a little extra for airfare if needed, in order to avoid those fares.
It's really a shame that honest citizens have to be concerned about carrying legal tender, in any amount. But, that's the world we live in.