I don't know why people never give the advice asked for.
If you're not counting, you're probably going to lose money, so the point is to lose as little as possible. Play the lowest limits and flat bet the table minimum. Play at crowded tables so the game is slow. Rules don't have as much of an effect as the hands per hour and the table minimum. Undoubtedly, your best bet is to find a $5 table, even if it has "crappy" rules, and play in the evenings when the tables are crowded. The Tropicana, I believe, is the most reliable source of $5 tables on the Strip, and I'm sure there's a ton downtown (but I don't go downtown very often so I don't know them). Luxor, Excalibur, Monte Carlo, and Treasure Island sometimes have $5 tables, but only during slow times. You can also try whatever casino Barbary Coast became (Bill's?), they used to have $5 tables as well.
If you are counting, then you need to worry about other things, among other things, the increased variance of spreading your bets and penetration.
But if you're not going to make a serious attempt at card counting, don't waste your vacation playing a half-assed game that's still EV negative because you're drunk and make BS mistakes. Just enjoy yourself, enjoy the time with your wife, budget a loss on gambling, and use anything over your budgeted loss to hire a hooker for a threesome.