The Spaniard's single deck game has a player advantage if just one five is missing from the deck.
In an 8 deck shoe, if all 6 players get a pair of fives, they each double down and get a 5 and the dealer shows a 5, has a 5 in the hole, hits for a 5 and another 5 to get a 20, then you have a huge advantage the rest of the shoe. Otherwise, counting just the fives in a shoe game is useless.